This site provides reliable information about
glucosamine and chondroitin for arthritis sufferers.
Chondroitin occurs naturally in the human body. It is part of a protein molecule that is believed to provide elasticity to the cartilage between bones and joints.
Commercially available products containing chondroitin are typically extracted from animal products such as shark or cow cartilage. These products are sold as a dietary supplement and are thought to reduce arthritis symptoms by reducing inflammation and improving cartilage elasticity and water retention. Chondroitin may also decrease the effect of enzymatic cartilage break down.
Typically, chondroitin is formulated with glucosamine and sometimes
with other anti-oxidants.
Chondroitin is thought to be safe; however, it is not
specifically approved for treatment in humans. Neither the Arthritis Foundation
nor the
The sale and distribution of chondroitin is not regulated by
the US Food and Drug Administration (FDA). Its use as an arthritis treatment
has not been approved by the FDA, and the FDA does not monitor the quality of
the manufacturing processes used to create these products.
There is some concern that chondroitin derived from cow cartilage could carry the prion responsible for mad cow disease, but this risk appears to be very low.
Several clinical studies suggest that chondroitin provides
pain relief, at least for some patients. And several studies suggest that that
cartilage damage is slowed after taking chondroitin.
“Trials of glucosamine and chondroitin preparations for OA (osteoarthritis) symptoms demonstrate moderate to large effects, but quality issues and likely publication bias suggest that these effects are exaggerated. Nevertheless, some degree of efficacy appears probable for these preparations.”
- Journal of American Medicine
(transcript free, full text available for a fee)
“ Studies showed chondroitin sulfate to be superior to placebo.”
The National Institutes of Health (NIH) is in the midst of clinical trials to evaluate glucosamine and chondroitin. Results are expected late in 2005. For additional information, see the NIH website:
Chondroitin Sulfate is the most common form.
Side effects are usually mild. The most common complaints are gas, indigestion, nausea, heartburn and softening of the stool.
This information is provided for research purposes only, and is not intended to replace your physician’s medical advice. Seek out the advice of a qualified medical professional before taking any over-the-counter supplements.